HOF and Entegris - Success is no coincidence

Successful collaborations are no coincidence, like this corporate partnership with Entegris Life Science in the field of bulk drug substance and cold storage from the USA. An international provider of robust cold storage and transportation. Entegris is known for its Aramus™ bag, among other things.

The goals of the cooperation include bundling joint technological know-how and successfully utilizing this synergy for customers. The advantages of the cooperation between HOF and Entegris enables pharmaceutical and biotechnological customers to find the best available solution for their individual process and at the same time to benefit from the many years of experience of both specialists.

As part of the partnership, a HOF Freeze-Thaw Unit (FTU) has already been installed at the newly created Life Sciences Technology Center in Billerica (Massachusetts, USA) to enable customers to leverage cold chain expertise, to optimize processes, reduce costs and accelerate time to market.

The world-class lab brings together tools and technologies from both manufacturers in one location where customers can test freeze/thaw equipment to determine which products meet their needs best.

The partnership with Entegris reinforces HOF's expert market leadership and makes it easier for U.S.-based customers to connect with HOF's equipment, gain experience and find their custom solution.

HOF looks forward to a long and successful relationship!

Review of ACHEMA 2022 – innovative – complex and successful!

With the theme of “A safe investment – now and in future, HOF systems are technological leaders”, HOF once again presented itself at this year’s international leading trade fair with many interesting new topics.

The exhibition stand was well frequented not only by existing customers, but also by numerous interested individuals who came to learn about new technologies, discuss new projects or simply to establish a personal contact.

We were particularly delighted with how popular the live presentations of the HOF SIRIUS robot-based loading and unloading system were.

But many discussions also focused on topics such as HOF CryoBlizzard central refrigeration – the new innovative technology that uses air as a refrigerant for freeze drying.

We would like to take this opportunity to thank everyone who visited us at ACHEMA 2022 and are already looking forward to welcoming everyone at the next ACHEMA in Frankfurt am Main from 10 to 14 June 2024.

“We are very satisfied with the feedback and we can see clearly how much our work is appreciated with regard to our innovative know-how.”
Alexander Hof/CEO

The innovative HOF water bath and debottling system

The innovative HOF water bath and debottling system was developed using state-of-the-art robot technology for automated defrosting of frozen plasma bottles, allowing the remaining frozen core and the surrounding liquid to be removed easily for further processing after the bottle has been cut open.

Learn more here and watch our detailed video >

„The HOF water bath and debottling system is a technologically highly innovative solution. Compact, reliable, safe and with state-of-the-art robot technology.“

Dr. Alexander Hof (CEO)

NEW – HOF product brochure

Our new product brochure titled “Technology – knowledge, experience and innovative thinking” contains our complete product range:

  • Freeze drying systems
  • Loading and unloading systems
  • Freeze Thaw Units
  • HOF waterbath & debottling system
  • HOF Customer Service

Among other things, it offers an insight into our role as a technological market leader, combined with topics such as “innovative pioneer” – power of innovation as a brand core, and provides information on our exacting claim “HOF quality is the sum of many success factors”.

The clear structure and design make it easy to find the topics you are interested in.

More >

HOF brand essence = innovative strength

HOF will continue to be among the medium-sized innovation elite in 2022

HOF is the national and international technological market leader in many new developments in the fi eld of freeze drying systems. After all, HOF‘s brand essence is ist innovative strength. To maintain and further expand the associated role of the innovative pioneer: ”is one of our defi ned goals and our customers should benefi t from this. Now and in the future“, says CEO Dr. Alexander Hof. As a professional market leader, it is therefore very important for HOF to have its innovative competence assessed by an independent party.

The Top 100 events, under the scientifi c direction of Prof. Dr. Nikolaus Franke and mentor Ranga Yogeshwar, are the only competition in Germany that has been awarding medium-sized companies for their innovation management under scientific direction for over 25 years on the market.

HOF has continuously faced the associated selection process since 2016 and has been awarded the TOP 100 seal for the seventh time and is, once again, one of the most innovative companies in Germany.

Construction of a new production hall

In the last years it became apparent, due to the continuous growth, that an extension of the production area was necessary. Hans-Georg Hof was responsible for the new building project. He explained: „We had long seen coming the need for the new hall".

 „ Accordingly, preparations - from planning to the building permit application- already started before Corona". „When the pandemic started, we started building – nobody knew where it was leading and we dug a large hole", he said with a laugh.
Implementation started quickly and, despite adverse circumstances in regard to material shortages and delivery delays, the construction of the new production hall was completed in August.

450 square meters of floor space for a production hall : it does not sound especially impressive.
But the height is quite imposing, because the new building has a 4770 cubic meters building volume- it is 11 meters high, extended over three floors, and there is also a four-meter-deep pit. What is the need of these height requirements? "In this way, we can set up the equipment over three floors in an identical design as at the customer’s premises on site " - this saves assembly time and finally offers customers security.

Two cranes - one with 40 and one with 20 tons of lifting capacity - were installed to cater for all needs. And an investment was also made in a cooling tower.

With the new production area, HOF has now successfully increased its capacity for installing freeze dryers in a vertical arrangement as a two-story design by 40% and doubled the capacity of its in-house refrigeration workshop.

The cost of the new building was around €3.35 million - plus investment in infrastructure, making the total project worth €3.8 million. "A good investment in the future," says Alexander Hof.

Pressemeldung HOF "Millionen-Investition in die Zukunft" >

Knowledge, competence and values - New HOF image brochure

Since the foundation of the company more than 30 years ago, it has always been important for HOF to convey a clear image company to its customers.

However, companies are also subject to the changing times. This leaves a mark on one‘s own corporate image, the same applies to HOF. Corporate messages have to be reconsidered, positioning has to be optimized.

In recent years HOF has continuously developed and has now grown to almost 300 employees.
This further development includes, among other things, the constant search for innovative solutions and this is only possible with excellent technological knowledge, creative curiosity and excellently qualified employees.

This also includes a special technological know-how and an extraordinary innovative strength. Supporting pillars and decisive success factors.

HOF is the professional market leader, a globally recognized company, you can rely on its competence. HOF’s guiding principle is based on values such as respect, fairness and loyalty in dealing with one another.

This is HOF, a living corporate philosophy,

enjoy reading >

For the sixth time in a row TOP 100

We are very pleased to announce that HOF Sonderanlagenbau GmbH from Lohra has once again made the leap among the best in the 28th edition of the TOP 100 innovation competition. And for the sixth time in a row!

Prof. Dr. Nikolaus Franke
Ranga Yogeshwar

“It is a great pleasure to be among the winners again. We would like to thank all employees for their motivation and innovative strength and of course our customers for the regular exchange of knowledge."

Kind regards,
Dr. Alexander Hof


HOF will also be among the medium-sized innovation elite in 2021

Since 2016, HOF has been awarded the TOP 100 seal for the sixth time and is once again one of the most innovative companies in Germany.
The TOP 100 seal was awarded for the 28th time and honors Germany's innovation elite in several categories. This award honors particularly innovative companies from a wide variety of industries. The award is based on an independent test based on a scientific system by the scientific director of TOP 100, Prof. Dr. Nikolaus Franke.

Which innovative measures particularly distinguished HOF, among others?

Here is a selection of the most important measures taken by HOF, based on the following categories:

Top management promoting innovation, innovation climate, innovative processes and organization, external orientation / open innovation and innovation success, as well as entrepreneurial reactions to the corona crisis.

  • The managing director initiates and pursues innovative development projects himself. In addition, special working hours are granted for innovation projects so that those involved Employees can act and react flexibly. At the same time, the idea of ​​innovation not only spans the products and services of HOF, but also the sustainability of the company.
  •  There is a daily and continuous exchange of knowledge between mechanical and electrical construction as well as software development. That promotes the individual personal idea development. At the same time, practical implementation in all Project phases are goal-oriented and accompanied intensively.
  • The in-house quality management manages and organizes the collection of ideas for the various areas. The evaluation and implementation is carried out by the management level supervised. In addition, an external QM consultant is involved in the management of the processes involved.
  • Meetings are held quarterly with the department heads and an external one Management consultant for quality and improvement management. There will be additional Ideas and innovations introduced are discussed, documented and followed up. Thus becomes a Processing or treatment of 100% of all submitted proposals is guaranteed.
  • Thus possible bottlenecks and delivery difficulties of individual suppliers in the Corona crisis can be compensated, exists for all components that we need for our systems, a flexible pool of suppliers.
  • Maintenance work on pharmaceutical freezers has been carried out for our customers in Japan Products conducted via web meeting. A team of experts was involved for three days and has the maintenance work of the systems is instructed via live transmission. There were also plants of our customers in Australia and USA set up under instruction via video conference, in operation taken and validated.
  • As a prophylaxis for the Covid emergency, a group of service technicians was established in the company optional in order to be quickly ready for service for customers in the event of service.

The scientific director is very impressed by the award-winning medium-sized companies: "The TOP 100 companies have consistently aligned themselves to be as innovative as possible," said Prof. Dr. Nikolaus Franke.

In essence, it was about the question of whether innovations are the result of a planned procedure or a coincidental product, i.e. the repeatability of innovation achievements. And about whether and how the corresponding solutions will establish themselves on the market

HOF has successfully asserted itself in this demanding selection process and will therefore again be one of the most innovative companies in Germany in 2021.

Award ceremony by mentor Ranga Yogeshwar

Instead of the previous award ceremony in summer, a year-end event is planned for November. The TOP 100 final as part of the German SME Summit on November 26, 2021, in the Forum am Schlosspark in Ludwigsburg.
The science journalist Ranga Yogeshwar will personally congratulate the successful companies, he has accompanied the innovation competition as a mentor for ten years.


CryoBlizzard - Next generation of freeze drying and blast freezing

HOF has developed a new process, which uses ambient air as a refrigerant that exceeds the current requirements for freeze drying and blast freezing in the long-run.

Currently, the entire industry is in upheaval due to the social and political rules and regulations in regard to climate change, generating a level of uncertainty for many operating companies. Frequently asked questions refer to the problem of environmental compatibility, official regulations and directives as well as the availability and price development of operating media. This concerns refrigeration in particular, as the established technologies in this field are increasingly restricted by political regulations, bans and shortages. For installations with a service life of more than 30 years, operating companies focus especially on future-proof design, reliability and quality of their plants. Energy efficiency, safety, selection of components, documentation and durability are also crucial factors.

[Translate to Englisch:]

HOF CryoBlizzard - a technology sets new standards

As an innovative market leader, HOF always puts emphasis on customer needs and market demands. Together with Mirai Intex ( as a partner, the HOF CryoBlizzard has been developed as a new technology for our market segment.

A HOF freeze dryer from 1998 was retrofitted especially for this R&D project. The plant is a freeze dryer with a batch capacity of 40 kg for insulin production. Before this retrofit, refrigeration was achieved by two refrigeration sets, each containing 12 kg of the refrigerant R404A (GWP100 = 3922). The process plant was controlled by a Siemens S5 control system.

Great performance with homogeneous temperature distribution

The overall retrofit has upgraded the lyo to a new refrigeration process, the HOF CryoBlizzard and to the current S7-1500 control system. With this new process, the refrigeration system consists of redundant cold air machines which are connected to a central primary tank in a modular system. The primary tank supplies the consuming units, such as shelf stack, ice condenser or blast freezer directly with the refrigerant medium and can therefore provide large capacities with homogeneous temperature distribution, all within a very short time. The usage of such a primary tank results in the fact that the consumption of cooling water and the power remain constant and no load peaks occur during the supply. Additionally, the cooling water consumption was reduced by half.

Air as refrigerant is free of charge and always available

The cold air machines from Mirai Intex are chillers which operate with air as a refrigerant using the Brayton cycle process. The maximum overpressure in the machines is 3 bar(a) and can be compared to that in a bicycle tire. This makes these machines particularly safe and environmentally friendly. Furthermore, no special requirements result in regards to the machine room set-up, employee training and recurrent testing. And in addition to all this, air as a refrigerant is free of charge and always available, has a GWP100 value of 0 (zero) and is therefore not affected by any regulations.

“As an innovative equipment manufacturer, we knew thatwe have to come up with a new way forward - for our customers. The advantages of air as a refrigerant are obvious. Air is available, non-flammable, non-toxic and poses no risk of suffocation. Air has no GWP value and is therefore not subject to the F-Gas Regulation or any other directives. That is the future!”, says Oliver Fleischer from the refrigeration engineering and service management department at HOF.

The HOF CryoBlizzard turbocompressor, oil-free and almost wear-free

The refrigeration circuit is driven by an air-bearing supported, oil-free turbo compressor–expander unit that runs with up to 88000 rpm and virtually no wear. The refrigeration medium is cooled in a heat transfer unit, integrated into the chiller. The air that is heated this way, is aspirated by the turbocharger and compressed (steps 1 to 2). Subsequently, the energy in the gas chiller is dissipated to the environment and cooled down (steps 2 to 3). In an inner heat transfer unit, the recuperator, the air is strongly cooled down (steps 3 to 4) and then relaxed for effective use in the expander (steps 4 to 5). This work is returned to compression. The energy is now absorbed through heating of the air in the cold medium/heat transfer unit (steps 5 to 6). After the air in the recuperator has been heated again (steps 6 to 1), it is aspirated by the compressor and the cycle starts anew.

With HOF CryoBlizzard - renewing existing systems as a retrofit or implementing new systems

The modular design enables the capacity of the HOF CryoBlizzard to be scaled up or down as needed. This allos its adaption from small freeze dryer units all the way to a central cooling system for complete factories. Existing plants can be retrofitted and new plants can be implemented. With the HOF CryoBlizzard, HOF has developed a future-proof solution for freeze drying and blast freezing which is not only safe for employees and the environment, but also sets new standards with regard to the quality and availability of the application. Therefore, the HOF CryoBlizzard is another alternative technology by HOF to solve the GWP-issue of synthetic refrigerants in the long-run.

In cooperation with the project partners:


Refolution Industriekälte GmbH

We are especially happy, that the technological magazine „DIE KÄLTE + Klimatechnik“ has published an article about our technology already in its most current issue. Source: Alfons W. Gentner Verlag GmbH & Co. KG, Fachmagazin „DIE KÄLTE + Klimatechnik“, Article "Natürlich am besten", issue 01.2020, pages 18 - 19.

For more information on the innovative development, please contact Mr. Oliver Fleischer (Phone: 0049 6462-9169-228 - Email: oliver.fleischer(at) or any other HOF representative.

Important about SIGRAPH and EPLAN 5

Since the existence of HOF Sonderanlagenbau GmbH all switchgear documentation (wiring diagrams) was prepared at HOF electrical engineering. From 1990 to 2004/2005 we used SIGRAPH and from 2004/2005 to 2012/2016 we used EPLAN 5, later EPLAN Electric P8.

Due to manufacturer-related changes we would like to draw your attention to the following announcements:

Sigraph announcement:

The CAE system SIGRAPH, used to create circuit diagrams until 2004, has already been discontinued by the manufacturer for some time. Economic processing of the circuit diagrams is therefore unfortunately no longer possible. We can therefore process changes in SIGRAPH diagrams only to a limited extent and must discontinue support for these circuit diagrams from 2022.

For larger modifications, we recommend converting the circuit diagrams to EPLAN P8.

EPLAN 5 announcements:

The CAE system EPLAN 5, used to create circuit diagrams between 2004 and 2016, has been replaced by the EPLAN P8 system. As of version EPLAN P8/2.8, EPLAN 5 can no longer run in a system environment. Furthermore, operation under Windows 10 is not released.
In the future, EPLAN 5 projects must therefore be migrated to P8 to enable further processing.

Bernd Becker (Head of Electronics Engineering)

"If modifications to your affected systems are planned, we will be happy to support you with a future-oriented solution."

Any questions?