premium pharma solutions
HOF Enterprise Group
Specialists as sought-after partners for industry
The HOF group of companies, with the companies HOF Sonderanlagenbau GmbH and HOF Prüfsysteme GmbH, has been in the possession of the central Hessian entrepreneur Hans-Georg Hof for several decades. Both companies are specialists in their branch, with their high level of know-how and many new innovative ideas laid the foundation for the high technological competence of the group.
Welcome to HOF
HOF Sonderanlagenbau GmbH has been the leading specialist for manufacturing
individual freeze drying systems, loading and unloading systems
and freezing and thawing equipment for over 30 years.
Focus on your product
Individually designed, planned and manufactured – with state-of-the-art technology
Power of innovation
to find answers
We let knowledge grow
Our know-how is the basis for your success
Communication & media
Knowing what is important
Contact
Headquarters:
HOF Sonderanlagenbau GmbH
Ludwig-Rinn-Str. 1-3
35102 Lohra
Germany
Phone + 49 6462 9169-0
Fax + 49 6462 9169-199
Mornshausen site:
HOF Sonderanlagenbau GmbH
Vor dem Langen Loh 2
35075 Gladenbach-Mornshausen
Germany
Phone + 49 6462 9169-0
Telefax + 49 6462 9169-199
News
HOF TECH-Innovation-Day 2025 – Focus on Sustainable Cooling Technologies and Processes
On November 12, we will officially open our doors in Marburg – and cordially invite you to be part of it.
A full day of practice, knowledge, and inspiration dedicated to the three core topics of the TECH-Innovation-Day:
- Annex 1 – Requirements and Implementation
- Use of Process Analytical Tools in Freeze Drying
- Sustainable Refrigeration Technologies and Processes
After highlighting the second focus area, we now turn to the third and final topic block, completing our series leading up to the HOF TECH-Innovation-Day 2025.
Sustainable Cooling Technologies and Processes
The demand for energy-efficient and environmentally friendly cooling technologies continues to rise – especially in sensitive applications such as freeze drying and freeze-thaw processes.
At the HOF TECH-Innovation-Day, we will explore current developments, regulatory frameworks, and practical solutions for a sustainable future in cooling technology for pharmaceutical applications.
In three exciting sessions, you will gain a comprehensive overview of new regulations, technical innovations, and successful industrial best practices.
Session 1:
F-Gas Regulation –
Impacts and Opportunities
Insights into current and upcoming EU F-Gas Regulation and REACH legislation. Which refrigerants will remain approved in the future? What transition periods and obligations apply to operators? Learn more about the background of these regulations and how to avoid compliance risks.
Session 2:
Alternative Cooling Technologies
This session focuses on innovative and sustainable cooling concepts designed to make processes future-proof and independent of regulatory restrictions.
In addition to the technologies themselves, practical implementations will be presented – including examples from HOF freeze-drying systems and HOF freeze-thaw solutions.
Session 3:
Case Study – Sustainable Freeze Drying in Practice
Gain deep insights into the real-world implementation of sustainable cooling technologies in industrial freeze drying. An industry user will share the entire journey – from planning and selecting suitable systems to on-site commissioning. Challenges such as process stability, energy efficiency, investment costs, and maintenance will also be addressed.
Roche Diagnostics GmbH
Look forward to practical insights:
Experience the future of sustainable cooling technology – from regulatory frameworks and alternative systems to proven industry applications.
Discover how innovative technologies using natural refrigerants, energy-efficient processes, and intelligent system solutions form the foundation for a climate-friendly and economically viable production.
Tomorrow starts today
“Sustainable cooling technologies are not a trend, but the logical consequence of responsible plant engineering.”
Fabian Plaum
(Sales Management)
What to expect at the HOF TECH-Innovation-Day
Annex 1 – Requirements and Implementation
How can the new Annex 1 guidelines be effectively implemented in practice?
- Technical lecture on Annex 1-compliant loading and unloading systems – including an overview of regulatory requirements and their technical implementation at HOF
- Practical industry case study
Application of Process Analytical Tools in Freeze Drying
How modern process analytical tools are transforming freeze drying and enhancing process safety:
- Basics and theory of mass spectrometry
- Case Study: Mass Spectrometry
Factory Tour & Personal Exchange
Experience HOF live – with an exclusive guided tour through our facilities in Lohra and Mornshausen,
on November 11 and 12, 2025, from 3:00 p.m. to 5:00 p.m.
Be there when innovation and practice meet on November 12 in Marburg – at the HOF TECH-Innovation-Day 2025.
Find all details about the program, topics, and registration on our landing page:
More about the TECH-Innovation-Day >
Mit freundlichen Grüßen
Yout HOF Team
HOF TECH-Innovation-Day 2025 – Focus on Application of Process Analytical Tools in Freeze-Drying
On November 12, leading experts from the pharmaceutical, biotechnological, and technical sectors will meet in Marburg to discuss the future of pharmaceutical production.
A full day of practice, knowledge, and inspiration, featuring the three key topics of the TECH-Innovation-Day:
- Annex 1 – Requirements and Implementation
- Application of Process Analytical Tools in Freeze-Drying
- Sustainable Refrigeration Technologies and Processes
After highlighting the first focus topic Annex 1 –
Requirements and Implementation in our previous issue, today we turn the spotlight on the second main topic:
Application of Process Analytical Tools in Freeze-Drying – Transparency in the Process
How can product quality in pharmaceutical freeze-drying be monitored even more precisely in the future?
Mass spectrometry opens up new insights – directly into the process. But how can this technology be efficiently integrated into existing systems without fundamentally changing the production environment?
Especially in validated production lines, the challenge is to combine stability and innovation.
Modern analytics should not only measure – but understand.
At the HOF TECH-Innovation-Day 2025, we will demonstrate how inline-capable mass spectrometry makes the freeze-drying process more transparent, safer, and more efficient – from development scale to large-scale production.
Gain practical insights into the use of modern process analytical tools, discover real-world applications, and take away valuable impulses for further enhancing process reliability in freeze-drying.
Look forward to fascinating insights:
A presentation on the use of modern, inline-capable mass spectrometry – including an overview of the technological fundamentals, system integration, and a practice-oriented case study.
Tomorrow starts today.
“Modern process analytics brings clarity to the details – making freeze-drying more precise and traceable.”
Johannes Kuhl
Certified Engineer
Sales Management
What else to expect at the HOF TECH-Innovation-Day
Sustainable Cooling Technologies and Processes
Sustainability, energy efficiency, and regulatory requirements in focus:
- Expert presentation on current regulatory requirements
- Technology overview of HOF cooling systems – techniques in comparison with advantages and disadvantages
- Practical example: Application of sustainable cooling technology at the HOF Pharma Blast Freezer and the FTU
Annex 1 – Requirements and Implementation
How can the new Annex 1 guidelines be effectively implemented in practice?
- Technical lecture on Annex 1-compliant loading and unloading systems – including an overview of regulatory requirements and their technical implementation at HOF.
- Practical industry case study
Factory Tour & Personal Exchange
Experience HOF on site – with an exclusive guided tour through our facilities in Lohra and Mornshausen.
On 11 and 12 November 2025, each from 15:00 to 17:00.
Stay tuned –
in the next editions we will present the further key topics.
More about the TECH-Innovation-Day >
With kind regards,
Yout HOF-Team
HOF TECH-Innovation-Day 2025 – Focus on Annex 1
On November 12, 2025, the HOF TECH-Innovation-Day in Marburg will bring expertise, technologies and practical experience together. A whole day full of insights, best practices and exchange information around the topic future of pharmaceutical production.
Now, we continue the event series and put the first focus topic in the spotlight:
Annex 1 – Requirements and Implementation
How can the new Annex 1 requirements be put into practice?
The new Annex 1 is already in force – but many questions remain:
How can existing production lines be upgraded to meet the new requirements without having to replace freeze dryers or filling machines?
Especially established systems are expected to further produce in a reliable way, while a complete reinvestment means enormous time and cost efforts. So, what are the solutions to remain compliant with Annex 1? That’s exactly what we will demonstrate at the
HOF TECH-Innovation-Day 2025.
And when planning new lines – whether small scale or large-scale production – the rule is: think of tomorrow today.
We will show the latest trends in loading and unloading systems, including robot-assisted loading and unloading of freeze dryers with HOF SIRIUS, and give you an exclusive preview of a new HOF product family that will set new standards.
You may also look forward to:
join us for a presentation on Annex 1 compliant loading and unloading systems – including an overview of the regulatory requirements and their technical implementation at HOF – as well as a practical case study.
Tomorrow starts today.
“Annex 1 brings clear requirements. Our task is to provide customers with future-proof loading and unloading systems that can be seamlessly integrated into both existing and new lines.”
Peter Schneider
(Sales Management)
Other topics await you at the HOF TECH-Innovation-Day, such as:
Sustainable Cooling Technologies and Processes
Sustainability, energy efficiency, and regulatory requirements in focus:
- Expert presentation on current regulatory requirements
- Technology overview of HOF cooling systems – techniques in comparison with advantages and disadvantages
- Practical example: Application of sustainable cooling technology at the HOF Pharma Blast Freezer and the FTU
Application of Process Analytical Tools in Freeze Drying
How modern process analytical tools transform freeze drying and increase process safety:
- Basics and theory of mass spectrometry
- Case Study: Mass Spectrometry
Factory Tour & Personal Exchange
Experience HOF on site – with an exclusive guided tour through our facilities in Lohra and Mornshausen.
On 11 and 12 November 2025, from 3 p.m to 5 p.m-
Stay tuned –
in the next editions we will present the further key topics.
More about the TECH-Innovation-Day >
With kind regards,
Your HOF-Team
HOF TECH-Innovation-Day 2025 – Save the Date
On November 12, 2025, the time has come: The HOF TECH-Innovation-Day will bring together people, technologies, and practical expertise. Today, we’re giving you a first look at the topics you can expect. Look forward to insightful expert technical lecture, exciting industry case studies, and forward-looking technologies for pharmaceutical production.
A compact program designed to inform, inspire, and foster exchange –
including an exclusive factory tour and a networking get-together in Marburg.
Three key topic areas will be in focus:
Annex 1 – Requirements and Implementation
How can the new Annex 1 guidelines be effectively implemented in practice?
- Technical lecture on Annex 1-compliant loading and unloading systems – including an overview of regulatory requirements and their technical implementation at HOF.
- Practical industry case study
Sustainable Refrigeration Technologies and Processes
Focus on sustainability, energy efficiency, and regulatory requirements:
- Expert technical lecture on current regulatory requirements
- Technology overview of HOF refrigeration systems – comparing techniques, advantages, and limitations
- Practical example: Implementation of sustainable refrigeration technology on the HOF Pharma Blast Freezer and FTU
Use of Process Analytical Tools (PAT) in Freeze-Drying
How modern process analytical tools are transforming freeze-drying and increasing process safety:
- Industry trends for newcomers and decision-makers
- Case study: Mass spectrometry – theoretical background and practical application as a PAT tool
Factory Tour & Networking
Experience HOF live –
with an exclusive guided tour of our facilities
in Lohra and Mornshausen.
On November 11 and 12, from 3:00 to 5:00 p.m.
Curious to learn more?
Soon, we’ll share more details about the full program and featured highlights.
More information will be available here >
Kind regards,
Your HOF-Team
